The Ingredients

ProRelease’s Topical Paradise formulation contains proprietary extracts from the following plants, selected through an exhaustive search for potent and safe extracts, and specially prepared as informed by ProRelease’s deep expertise in pain management and in the rigors of formulation:

  • Belamcanda chinensis: prepared for direct ryanodine-receptor (RyR1-selective) inhibition that fights muscle spasms, without affecting cardiac muscle and smooth muscle. Belamcanda chinensis is on the European Pharmacopoeia.
  • Corydalis ambigua: works through an unusual antinociceptive mechanism involving peripheral dopamine receptors and possibly excitatory receptors such as NMDA-R. Dopaminergic neurons are also protected by compounds in Humulus lupulus. Corydalis has a long history of use in traditional Chinese medicine.
  • Humulus lupulus: rich in terpenophenolics inhibiting both phases of the formalin test. It is revered in Ayurvedic and Native American medicines for pain and wounds.
  • Helichrysum italicum: rich in powerful anti-inflammatory flavonoids including Z-ligustilide which inhibits not only inflammation but also destructive metalloproteinase (MMP) activity. H. italicum is known to work via multiple effects, including inflammatory enxyme inhibition, free-radical scavenging activity, and corticoid-like effects.
  • Zingiber zerumbet: from the universally-revered genus of “ginger”, this plant contains powerful neuroprotective and even neuroregenerative sesquiterpenes.